Author: Arnold

Introduction: Anxiety, Avocado Toast, and the Gut-Brain Connection

As a millennial, stress and anxiety have always been familiar companions. Balancing work, social pressures, and the elusive idea of self-care felt like an endless battle. My Instagram feed was full of friends promoting meditation apps, yoga sessions, and avocado toast brunches as cures for mental fog and emotional fatigue. But behind curated images, the daily reality was persistent anxiety and unpredictable moods. That’s when I stumbled upon something new: the gut-brain connection.

Discovering the Gut-Brain Axis: It’s More Than Just Yogurt

Initially, probiotics to me meant yogurt commercials or kombucha in fancy bottles. But deeper research led me to the term “psychobiotics,” probiotics that specifically influence mood and mental health. The idea that gut bacteria could influence my anxiety and stress levels intrigued me. Could this be the missing link in my mental health journey?

Gut Health 101: Understanding the Microbiome

The human gut is home to trillions of bacteria, fungi, and viruses, collectively known as the microbiome. These microbes do more than aid digestion—they produce neurotransmitters like serotonin and dopamine, regulate stress hormones like cortisol, and modulate inflammation. An imbalanced gut microbiome (dysbiosis) is increasingly linked to anxiety, depression, and mood swings.

Millennials and Mental Health: The Unspoken Epidemic

According to recent statistics, millennials report higher stress, anxiety, and depression levels compared to previous generations. Factors like financial insecurity, social media pressures, and chronic work stress play major roles. I was part of this statistic, frequently feeling overwhelmed and anxious without clear reasons.

My Experiment with PS128: A Promising Psychobiotic

After extensive research, one probiotic strain caught my attention—Lactiplantibacillus plantarum PS128. Originally isolated from fermented Taiwanese vegetables, PS128 was different due to its documented ability to affect neurotransmitter pathways and stress responses.

Scientific studies showed PS128’s potential benefits, including improved mood, reduced anxiety, and better sleep quality. Encouraged by clinical data and positive testimonials, I decided to give it a try.

Starting PS128: Skepticism and Small Changes

I started with a daily capsule containing PS128, pairing it with breakfast to form a habit. Initially, I felt skeptical. How could bacteria in a capsule significantly impact my mood? The first week passed uneventfully, but by the end of the second week, I noticed subtle shifts.

My sleep quality improved—fewer midnight awakenings and more restful mornings. My baseline anxiety felt less overwhelming. These weren’t miraculous changes, but they were noticeable and meaningful.

Science Behind PS128: Why it Works for Mood

Delving into research, I learned that PS128 acts on the gut-brain axis by increasing serotonin and dopamine levels in the brain. Animal studies demonstrated reduced stress hormones like cortisol and enhanced production of mood-stabilizing neurotransmitters. This scientific validation reassured my skeptical mind that my experiences weren’t just placebo effects.

Clinical Studies and Real-World Impact

Human clinical studies echoed my experience. A study involving stressed adults revealed PS128 significantly improved mood, anxiety, and sleep quality over eight weeks. Another trial with children facing anxiety and behavioral issues also reported significant improvements. The consistency across research and personal experience made PS128 feel increasingly credible and reassuring.

Probiotics in a Holistic Mental Health Routine

While PS128 was helpful, mental health demands a holistic approach. Alongside PS128, I incorporated regular physical activity, mindfulness meditation, and a balanced diet rich in fiber and nutrients that support gut health. These combined efforts amplified the positive effects of PS128, highlighting the power of holistic wellness.

Overcoming Stigma: Millennials and Mental Health Conversations

Discussing gut health and probiotics opened up new conversations with my friends about mental health. Millennials often normalize anxiety and burnout, rarely discussing actionable solutions. Sharing my journey helped break the stigma, encouraging others to consider gut health and psychobiotics as valuable tools in mental health management.

A Balanced Gut for a Balanced Life: Sustaining Positive Changes

Months into taking PS128, my mood felt significantly more balanced. I handled stress better, slept deeply, and experienced fewer anxious episodes. Maintaining gut health through PS128 became a cornerstone of my mental wellness routine, demonstrating the long-term value of gut-brain care.

Future of Gut-Brain Research: Hope for Millennial Mental Health

Ongoing research continues to validate psychobiotics like PS128 as promising tools for mental health. Future studies aim to further unravel the mechanisms behind gut-brain interactions, potentially paving the way for more personalized probiotic treatments.

Conclusion: A Personal Invitation to Explore Gut Health

My journey with PS128 taught me the profound connection between gut health and mental wellness. For millennials battling anxiety, stress, or emotional fatigue, exploring psychobiotics could offer valuable relief. It’s not a miracle cure but rather a vital piece of a holistic mental health puzzle.

I encourage fellow millennials to explore this innovative approach, embracing science-backed solutions like PS128 to enhance emotional well-being and resilience in our increasingly demanding world.

 

1. Introduction

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms. Emerging evidence highlights the gut-brain axis as a significant therapeutic target, with probiotics like Lactiplantibacillus plantarum PS128 showing promising results.

2. The Gut-Brain Axis in Parkinson’s

Parkinson’s often initiates in the gastrointestinal tract, with symptoms such as constipation preceding motor symptoms. Changes in gut microbiota and gut inflammation are hypothesized to contribute to Parkinson’s progression by influencing alpha-synuclein aggregation and neuroinflammation.

3. Overview of PS128

PS128, isolated from fermented Taiwanese vegetables, is categorized as a psychobiotic due to its unique influence on the gut-brain connection. It modulates gut microbiota, neurotransmitter pathways, and inflammatory processes, potentially improving both motor and mood-related symptoms.

4. Clinical Evidence: PS128 in Parkinson’s Patients

A pilot clinical trial with 25 Parkinson’s patients demonstrated significant motor improvements, prolonged “ON” times, improved quality of life, and reduced inflammation markers after 12 weeks of daily PS128 supplementation. These results suggest PS128 could complement standard Parkinson’s medications effectively.

5. Anecdotal Evidence and Real-Life Outcomes

Patient experiences reinforce clinical findings. Examples include Liu, who regained fine motor skills, and Hexiang, who demonstrated improved speech, mood, and manual dexterity. Such real-world testimonials underscore PS128’s meaningful impact on daily functioning and quality of life.

6. Non-Motor Symptom Improvements and Mechanisms

Research indicates PS128 can alleviate constipation, improve mood and sleep, and reduce anxiety. Animal studies show it enhances intestinal motility, serotonin signaling, and reduces inflammatory processes via microRNA regulation.

7. Safety Profile and Administration Guidelines

PS128 is GRAS-certified, safe, and well-tolerated at recommended dosages (50-100 billion CFU/day). Clinical trials and widespread usage have reported no significant adverse effects.

8. Current Limitations and Future Research Needs

The current pilot trial data, though promising, necessitates larger, placebo-controlled studies to conclusively establish efficacy and further elucidate mechanisms of action. Future research must also consider strain-specific effects.

9. Clinical Implications and Recommendations

PS128 could significantly enhance Parkinson’s management strategies, particularly regarding motor function, non-motor symptoms, and overall quality of life. It should be integrated as a complementary approach within a comprehensive care plan involving medication, diet, exercise, and mental health interventions.

10. Conclusion

PS128 presents as a promising, safe, and effective probiotic supplement for enhancing Parkinson’s care. Ongoing research and further clinical trials are critical to solidifying its role in holistic Parkinson’s management.

References

• ClinicalTrials.gov study NCT04389762
• Lu et al. Clinical trial results
• Liao et al. Gut microbiota and microRNA mechanisms
• Strain-specific caution studies (journals.sagepub.com)
• PS128 Safety Data (Wikipedia)

Introduction

Omega fatty acids, notably Omega-3 (docosahexaenoic acid [DHA] and eicosapentaenoic acid [EPA]) and Omega-6 (gamma-linolenic acid [GLA] and arachidonic acid [AA]), have been extensively studied for their roles in neurological and psychological health. This meta-analysis critically examines existing research to evaluate the efficacy of these fatty acids in various conditions, including mood disorders, cognitive functioning, neurodevelopmental disorders, and neurodegenerative diseases.

Omega-3 Fatty Acids: Mechanism and Clinical Impact

Neurophysiological Mechanisms

EPA and DHA integrate into neuronal cell membranes, facilitating fluidity and permeability, essential for neurotransmission. They modulate neuroinflammatory pathways, reducing pro-inflammatory cytokines and oxidative stress, which have been implicated in numerous neurological disorders.

Depression and Mood Disorders

A significant body of research supports the antidepressant properties of Omega-3 fatty acids. A 2018 meta-analysis involving 26 randomized controlled trials (RCTs) with over 2,000 participants indicated substantial benefits, particularly with EPA-rich formulations (≥60% EPA), showing reduced depressive symptoms (standardized mean difference [SMD] = -0.28; p=0.004) (Liao et al., 2018).

Further, Grosso et al. (2014) analyzed 19 studies (11 clinical depression and 8 subclinical depression), revealing a moderate but consistent efficacy (SMD = 0.38), highlighting that EPA-rich supplements significantly improved depressive symptoms compared to placebo.

ADHD and Cognitive Function in Children

Studies investigating Omega-3 supplements, particularly EPA and DHA, in attention deficit hyperactivity disorder (ADHD) reveal modest but promising results. A systematic review indicated small yet statistically significant improvements in attention span, impulsivity, and hyperactivity (Bloch & Qawasmi, 2011). However, efficacy varies across studies, and overall consensus highlights moderate benefits rather than robust clinical changes.

Cognitive Aging and Dementia

Regarding cognitive decline and dementia, research outcomes have been mixed. Cochrane reviews and meta-analyses have consistently demonstrated limited evidence for reversing cognitive impairment or significantly delaying Alzheimer’s disease progression with Omega-3 supplements. Some studies have shown marginal cognitive improvements in healthy older adults, yet these results lack consistency across various cognitive measures (Mazereeuw et al., 2012).

Omega-6 Fatty Acids: Clinical Implications

Mechanisms of Action

Omega-6 fatty acids like AA typically induce pro-inflammatory pathways. However, specific derivatives like GLA metabolize into dihomogamma-linolenic acid (DGLA), which generates anti-inflammatory prostaglandins, indicating nuanced biological roles.

Anti-inflammatory and Neuropathic Health

Research highlights that GLA supplementation, notably through evening primrose oil, demonstrates efficacy in alleviating diabetic neuropathy and nerve-related discomfort, although robust data on cognitive improvement remains limited. A meta-analysis published in BMC Complementary Medicine and Therapies (2024) emphasized the beneficial anti-inflammatory potential of GLA, yet its application in neurodegenerative diseases remains inadequately explored.

Comparative Meta-Analysis of Omega-3 and Omega-6

Clinical Efficacy

A meta-analytic comparison of Omega-3 and Omega-6 fatty acids across psychological and neurological disorders reveals distinct patterns:

• Omega-3 (particularly EPA-rich formulations) shows consistent efficacy in mood disorders, especially depression.
• Omega-3 demonstrates moderate efficacy in ADHD and cognitive functions in young populations.
• Omega-6 GLA offers limited yet notable efficacy in neuropathic and inflammatory conditions but lacks sufficient evidence for cognitive or psychological disorders.

Safety and Dosage Recommendations

Clinical guidelines recommend EPA-rich Omega-3 supplements (≥60% EPA) at doses around 1 gram per day for depression and mood stabilization. DHA-focused formulations have not demonstrated equivalent efficacy in mood disorders but remain essential for overall brain health.

For Omega-6 supplementation, caution is advised due to the pro-inflammatory potential of AA. Thus, maintaining a balanced ratio between Omega-6 and Omega-3 fatty acids is crucial, ideally ranging from 1:1 to 4:1, contrasting starkly with typical Western diets, which can reach ratios of 10:1 to 30:1, promoting inflammation and associated neurological dysfunction.

Implications for Clinical Practice

Depression Treatment

Integrating Omega-3 fatty acids, specifically EPA-rich supplements, into treatment protocols for depression can offer substantial adjunctive benefits. Clinicians should consider incorporating these supplements in comprehensive treatment plans alongside conventional antidepressants and psychotherapeutic interventions.

ADHD Management

For pediatric populations, Omega-3 supplements may serve as a complementary approach to conventional ADHD treatments, showing modest improvements in behavioral and cognitive symptoms. However, expectations should remain realistic regarding the magnitude of therapeutic outcomes.

Neurodegenerative Disease Prevention

Current evidence does not support Omega-3 or Omega-6 supplementation as effective standalone interventions for neurodegenerative diseases like Alzheimer’s. Still, they can potentially contribute to a preventative nutritional strategy emphasizing dietary balance and anti-inflammatory dietary patterns.

Future Research Directions

Further large-scale, long-term randomized controlled trials are essential to elucidate the specific cognitive and psychological benefits of both Omega-3 and Omega-6 fatty acids. Particularly, studies exploring the potential synergistic effects of these supplements in combination therapies warrant additional investigation.

References and Links to Studies

• Liao Y et al., “Efficacy of Omega-3 PUFAs in Depression” (2018). PubMed Link
• Grosso G et al., “Role of Omega-3 Fatty Acids in Depression” (2014). PLoS ONE Link
• Bloch MH & Qawasmi A., “Omega-3 fatty acid supplementation for the treatment of children with ADHD: A systematic review and meta-analysis.” (2011). BioMed Central Link
• Mazereeuw G et al., “Effects of Omega-3 Fatty Acids on Cognitive Performance: A Systematic Review and Meta-analysis.” (2012). MDPI Link
• Gamma-Linolenic Acid – BMC Complementary Medicine and Therapies (2024). BMC Link
• Omega-3 and Omega-6 fatty acid mechanisms – Linus Pauling Institute. Oregon State Link

Conclusion

In conclusion, Omega-3 fatty acids, particularly EPA-rich supplements, exhibit significant potential for treating mood disorders and providing modest benefits in pediatric cognitive and behavioral conditions. Conversely, Omega-6 fatty acids, specifically GLA, show promise in neuropathic and inflammatory disorders but lack substantial evidence supporting cognitive health benefits. Balancing the dietary intake of Omega-3 and Omega-6 remains crucial to optimizing neurological and psychological outcomes. Further rigorous research will be essential in defining precise clinical applications and enhancing therapeutic efficacy.

 

1. Understanding the Daily Struggles of Parkinson’s Caregiving

As a healthcare professional working closely with Parkinson’s patients and their families, I see firsthand how caregiving can be both rewarding and exhausting. The slow progression of symptoms—tremors, stiffness, slowed movement—brings emotional and physical challenges not only for the patient but also for the caregiver.

Many caregivers share that mornings are the hardest. Dressing, eating, and even getting out of bed can take twice as long as before. Mood fluctuations and anxiety often add another layer of complexity. Over time, these daily struggles take a toll, leaving caregivers feeling helpless and in search of even the smallest improvements.

While there is no cure for Parkinson’s, small interventions that improve quality of life can make a profound difference for both patient and caregiver. One emerging area of interest is gut-brain health, and specifically, the role of a unique probiotic strain called PS128.

2. Why Gut Health Matters in Parkinson’s Disease

Parkinson’s is classically known as a neurological disorder, but research now shows it also significantly affects the gut. In fact, many patients experience gastrointestinal issues such as constipation or bloating years before motor symptoms appear. This has led to growing recognition of the gut-brain axis—a communication network between the digestive system and the central nervous system.

When the gut microbiome is imbalanced, it can influence the brain through immune responses, hormonal pathways, and neurotransmitters like dopamine and serotonin. Since Parkinson’s involves the degeneration of dopamine-producing neurons, supporting gut health may have a beneficial effect on mood, cognition, and even movement.

This is where psychobiotics—probiotics that positively affect the gut-brain axis—come into consideration.

3. Introducing PS128

PS128 is a specific probiotic strain, Lactiplantibacillus plantarum PS128, originally isolated from fermented Taiwanese vegetables. Unlike typical probiotics focused on digestion alone, PS128 is a psychobiotic, meaning it may help regulate the gut-brain axis by:

• Promoting healthy gut flora
• Modulating stress hormones like cortisol
• Supporting neurotransmitter pathways for dopamine and serotonin

These mechanisms make PS128 an interesting complementary option for managing non-motor symptoms and supporting overall quality of life in Parkinson’s patients.

4. What the Research Says About PS128 in Parkinson’s

Clinical evidence, while still emerging, is promising:

• 12-Week Pilot Study in Parkinson’s Patients
  In a pilot trial, 25 Parkinson’s patients supplemented with PS128 for 12 weeks. Results showed an 11–14% improvement in motor scores measured by the Unified Parkinson’s Disease Rating Scale (UPDRS), along with better quality-of-life scores. Importantly, no serious side effects were reported.
• Improvements in Mood and Sleep
  In adults under high stress, PS128 supplementation has been shown to improve sleep quality, reduce anxiety, and enhance mood regulation—issues that commonly affect Parkinson’s patients.

These findings do not indicate that PS128 replaces medication or halts disease progression. Rather, it may serve as a gentle adjunct, improving certain symptoms that matter greatly in daily life.

5. Real-Life Outcomes

Beyond clinical trials, there are documented caregiver accounts of small but meaningful improvements:

• Hexiang’s Experience
  After several months of PS128 supplementation, Hexiang, a 75-year-old patient, regained enough hand control to peel a mango independently—a task he hadn’t managed in over a year. His caregiver also noticed clearer speech and better mood stability.
• Mr. Liu’s Story
  Mr. Liu, with early-onset Parkinson’s, found that within the first month of taking PS128, his fine motor control improved enough to button his shirts again. He reported better mental clarity and reduced fatigue.

For caregivers, these changes translate to less frustration and more moments of independence for their loved ones.

6. How to Integrate PS128 Safely

In my professional experience, PS128 is well tolerated and easy to integrate into a care routine. Here are general recommendations:

• Take one capsule daily, ideally with meals.
• Do not discontinue prescribed Parkinson’s medications.
• Monitor for any changes in mood, sleep, or motor control.
• Always consult a neurologist or physician before starting any supplement.

Most families report noticing mood or sleep improvements within 2–4 weeks, with potential motor benefits after 8–12 weeks.

7. Combining PS128 with Holistic Care

Managing Parkinson’s effectively often requires a multifaceted approach:

• Balanced nutrition rich in fiber and antioxidants
• Gentle, regular exercise or physiotherapy to maintain mobility
• Occupational therapy for daily living tasks
• Social engagement to prevent isolation and depression
• Stress management techniques like mindfulness or breathing exercises
• Appropriate medications tailored to the patient’s needs
• Gut-brain support like PS128 as a complementary tool

This layered approach provides the best chance of maintaining independence and quality of life for as long as possible.

8. Common Caregiver Questions

Is PS128 safe?
Yes. It is GRAS-certified (Generally Recognized as Safe) and has undergone clinical testing in both children and adults without serious adverse effects.

Does it replace standard Parkinson’s treatment?
No. It serves as a complement to, not a replacement for, conventional therapies.

How do I know if it’s working?
Keep a simple journal tracking sleep, mood, motor ability, and emotional wellbeing. Look for gradual changes rather than dramatic improvements.

What if there is no benefit?
It is safe to discontinue. PS128 is not harmful but may not work for everyone.

9. Why Small Improvements Matter

As a healthcare professional, I often remind caregivers that Parkinson’s care is about quality of life, not perfection. A steadier hand that can hold a spoon, a better night’s sleep, or a brighter mood may seem like small things—but they create enormous relief for patients and their families.

PS128 is not a cure. But if it can bring even minor improvements, it can lighten the caregiver’s load and restore a sense of hope.

10. Key Research References

1. Lu et al. (2021) – 12-week pilot study showing improved motor function and quality of life in Parkinson’s patients.
2. Liao et al. (2020) – Demonstrated mood and sleep improvements in stressed adults taking PS128.
3. Wu et al. (2021) – Showed ADHD symptom improvement in children with Tourette’s syndrome supplemented with PS128.
4. Documented patient experiences, including Hexiang and Mr. Liu, reflecting small but meaningful functional gains.

Final Thoughts

As someone who has worked with countless Parkinson’s patients and their families, I understand the emotional weight of caregiving. While no single supplement or therapy can reverse the disease, tools like PS128 may offer gentle, evidence-backed support for mood, motor control, and overall wellbeing.

If you’re considering adding PS128 to your loved one’s care plan, consult their healthcare provider and approach it as one part of a holistic strategy. Together, small steps can lead to meaningful improvements.

You are not alone in this journey. Healthcare professionals, support groups, and emerging research are here to help you and your loved one live each day with more dignity and comfort.

Hello, fellow parent 🌸

Every morning feels like a tightrope walk.

You guide your child through breakfast. You coax them into their clothes. Sometimes, they’re calm. Other times, a meltdown explodes without warning.

I know this dance well. My daughter, Mei, 8 years old, was diagnosed with autism and ADHD. We love her fiercely—but the challenges? They’re heartbreaking.

Speech therapy, sensory breaks, mindfulness apps, schedule charts… we tried it all. And yet, some mornings, Mei still seemed lost in worry or overwhelm.

Then, a friend suggested something new: PS128. A probiotic she’d read about in science journals. “It might help with mood and focus,” she said softly.

Cue skepticism. Another supplement?

But as we dove in, I discovered something gentle, promising—and worth sharing with you, mom to mom.

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What is PS128?

PS128 stands for Lactiplantibacillus plantarum PS128—a specific strain of probiotic discovered in Taiwanese fermented vegetables.

But let’s skip the bio jargon. PS128 is a psychobiotic: a friendly gut bacterium that can gently support mood, behavior, and cognitive clarity.

It’s not a medicine. It’s not a cure. Think of it as a tiny helper in your child’s gut, working alongside therapies and routines you already trust.

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Research on PS128: Autism Trials

One of the strongest pieces of evidence comes from a 2019 randomized, double-blind, placebo-controlled trial in Taiwan involving boys ages 7–15 with autism spectrum disorder.

In just four weeks of PS128, these children showed:

• Less defiance and oppositional behavior

• Better attention, especially in younger kids

• Reductions in anxiety and rule-breaking

This wasn’t a small survey—it was a rigorous clinical trial showing real improvements in behavior.

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Real-world data supports lab studies

A real-world Italian study (Mensi et al., 2021) involved 131 autistic children and adolescents who took PS128 or other probiotics.

Results?

• Children taking PS128 showed greater behavioral improvement

• Fewer side effects compared to other probiotics

• Notably stronger benefits in younger children

This study echoed clinical trials, underscoring that PS128 isn’t just lab theory—it’s working in real families. You can read the details here.

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PS128 + Oxytocin: Synergy in Therapy

What if a probiotic and hormone therapy worked even better together?

In a 2021 MDPI trial, autistic children took PS128 alongside oxytocin over 28 weeks.

Results showed significant improvements in:

• Social responsiveness

• Behavior checklists

• Overall clinical impressions

This suggests PS128 might enhance traditional therapies—a hopeful option for families exploring combined approaches.

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PS128 & ADHD: More Than a Side Benefit

Kids with Tourette’s often have ADHD too. A 2021 PS128 clinical trial involving children with Tourette’s syndrome showed:

• No change in tics

• But significant improvements in ADHD symptoms—especially attention and impulse control

That’s important for our neurodivergent children who fight double battles. PS128 may help both, even if it’s not treating the tic itself.

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How PS128 Helps: Simple science

Picture your child’s gut as their home base.

If the floors are messy (bad bacteria), the brain’s signals get jumbled. PS128 helps tidy things:

1. Promotes friendly gut bacteria

2. Reduces gut inflammation

3. Boosts mood molecules like serotonin and dopamine

In short: a happier gut can help a calmer child—even on stressful days.

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It’s not a cure. It’s a helpful part of everyday care

We used PS128 alongside:

• Occupational therapy

• Speech support

• Predictable routines

• Outdoor time and movement breaks

• Simple diet (whole foods + healthy fats)

By 2 weeks: Mei slept more deeply.
By 4 weeks: we saw fewer classroom outbursts.
By 8 weeks: books and boards felt easier. Change. It happened.

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Real mom stories 💛

Izzy (Teen, Autism):

“New shoes. No tears. For the first time ever.”
Mom says PS128 helped her adjust to change. Read Izzy’s story here

Another mom:

“It’s cut my son’s anxiety in half.”
A heartfelt note from a Facebook parent group.

These stories mimic my own. Small shifts. Quiet celebrations.

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Safety & dosing

• Licensed as Neuralli MP, containing 60 billion CFU PS128

• GRAS (Generally Recognized as Safe) certified

• No serious side effects in trials involving kids aged 5–18

• We started with ½ capsule, mixing with yogurt or milk

• Increased to a full capsule after two weeks

• Always consult your pediatrician if child is on other meds

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Common questions

Is it safe for toddlers?
Studies include children as young as 5. Your pediatrician can advise on younger ones.

How soon results appear?
Trials saw behavioral improvements in just 4 weeks; many moms report changes around 8 weeks.

Is it a cure?
No. It helps with mood, attention, behavior—not autism or ADHD as diagnoses.

What if there’s no improvement?
Withdraw after 8–12 weeks. It’s gentle and doesn’t harm.

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Holistic support model

Our care plan included:

• Routine (predictable schedule)

• Therapy (OT, speech, counseling)

• Nutrition (whole grains, veggies, healthy fats)

• Exercise (daily movement)

• Emotional tools (mindfulness, breathing apps)

• PS128 (as a gut-brain ally)

This multimodal approach allowed us to celebrate every small win—and they add up.

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Sources & Research Studies

1. Liu et al., 2019 – 4-week RCT trial in autistic boys aged 7–15 showed improved attention and reduced defiance/opposition. Read on PubMed

2. Mensi et al., 2021 – Real-world observational study with 131 ASD children/adolescents confirmed safety and behavioral improvements with PS128. Read on MDPI

3. Wu et al., 2021 – RCT involving Tourette’s kids revealed ADHD symptom improvements with PS128. Read here

4. Liao et al., 2021 – Combined PS128 + oxytocin therapy in ASD yielded enhanced social and behavioral metrics. Read study

5. Additional animal studies show PS128 improves brain neurotransmission and reduces neuroinflammation—pointing to broader gut-brain effects.

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Final thoughts from my mom heart 💗

I know how exhausting life can feel when raising a neurodivergent child.

But I promise—small things matter:

• A day with one fewer meltdown

• A better night’s sleep

• A calmer morning routine

PS128 gave our family just that: some calm, some focus, some restored hope.

If you and your child could use a little help—embrace this gentle option. Talk to your pediatrician, give it 8 weeks, and track any changes you see.

You’re not alone. I’m here—pushing, hoping, loving alongside you.

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Love and sisterhood,
Mom of Mei (and so many small miracles)

Many products on supermarket shelves now boast of containing Docosahexaenoic Acid (DHA), eicosapentaenoic acid (EPA), and Arachidonic Acid (AA) in their formulations, but what do these abbreviations mean?

All of these letters signify essential fatty acids that our brains need for development. DHA is short for docosahexaenoic acid, the most abundant fatty acid in our brains. Together with EPA and AA, these fatty acids play important roles in the functions of our brains, eyes and nervous systems. EPA and AA help transport messages through our nerves, while DHA is responsible for many regulatory and building functions in our bodies, some of which are highlighted below.

According to a study published by the U.S. National Institute of Health, DHA helps improve the memory functions of healthy young adults. The study landmarks the first time significant positive results are seen in the general population, thanks to the findings of serious improvement in working and long-term memories in men and women.

For men, short-term memory, like remembering phone numbers and carrying out complex tasks, improved greatly, while Women showed better signs of improvement when it comes to retaining long-term memories like dates and occasions.

It’s not just adults though. For children, DHA is important because it aids their still-developing brains, eyes and nervous systems. But also, a study has shown that DHA helps children sleep an extra good full hour.

Sleep is important in children because it is the time when their brains can process the things they learned in their waking hours, and their rapidly developing bodies can catch up. Without good quality sleep, children tend to slow their development, physically, mentally, and socially.

Having an abundant supply of DHA in their brains shows that children experience fewer sleep disturbances, even if they have clinical-level sleep problems. The double-blind, randomized, placebo-controlled study also reported a full 58-minute addition to the children’s average sleep time, with fewer wake episodes and night wakings.

DHA not only helps physical development, but it also impacts mood and mental health.

National Center for Biotechnology Information (NCBI) published a study that shows a direct link between DHA and reduced risk of depression. In another study that is randomized and placebo-controlled, it also greatly reduces aggression and impulsivity. This study showed a significant change in healthy young males in terms of their proclivity to violence toward another person, as well as a huge jump to lesser impulsivity from otherwise aggressive individuals once they are put on a DHA-supplemented diet.

DHA is also said to help in managing Attention Deficit Hyperactivity Disorder (ADHD), helping children decrease their attention problems by at least 15%.

Our bodies cannot make these key essential fatty acids, so ensure that you and your child are getting adequate amounts, make sure to take Efamol Efalex Brain Formula Capsules.

Free from sugar, gluten, milk derivatives, and artificial colours and flavours, Efalex is an advanced combination of Omega 3 and 6 fatty acids that make sure that your brain gets all the nutrients it needs.

Welma Stonehouse, Cathryn A Conlon, John Podd, Stephen R Hill, Anne M Minihane, Crystal Haskell, David Kennedy, DHA supplementation improved both memory and reaction time in healthy young adults: a randomized controlled trial, The American Journal of Clinical Nutrition, Volume 97, Issue 5, May 2013, Pages 1134–1143, https://doi.org/10.3945/ajcn.112.053371
University of Oxford. (2014, March 6). Higher levels of omega-3 in diet are associated with better sleep, study shows. ScienceDaily. Retrieved April 15, 2020 from www.sciencedaily.com/releases/2014/03/140306103931.htm
Ginty, A., Muldoon, M., Kuan, D., Schirda, B., Kamarck, T., Jennings, J., Manuck, S. and Gianaros, P., 2020. Omega-3 Supplementation And The Neural Correlates Of Negative Affect And Impulsivity.

When it comes to bacteria, most people’s first reaction is that it is bad for your health. However, did you know that not all kinds of bacteria are bad for you?

Our bodies are wonderfully complex, and inside our guts is a whole ecology of “germs” that greatly influence our health. The “good” ones are called probiotics, prebiotics, and psychobiotics, and in this article, we are discussing what they do for our bodies and why it’s important to keep them replenished and thriving:

In our digestive systems, probiotics live in complex communities of microorganisms in what is almost a whole other organ when it comes to helping our metabolism. Known as the gut flora or microflora, they are made of live bacteria responsible for regulating our digestion and providing us with vital vitamins and minerals. The “good” bacteria in the gut flora are called probiotics.

Probiotics have different strains (1), with Lactobacillus and Bifidobacterium as the two main ones. We find them when we eat probiotic foods like yoghurt and kimchi. However, it’s also possible to lose the balance of good bacteria when we have to take antibiotics. This can lead to diarrhea, irritable bowel syndrome, or other stomach-related illnesses.

But beyond helping us with digestion, probiotics also help lower cholesterol, enhance our immune systems, facilitate weight loss, and even improve skin against disorders and allergies (2). Making sure that we have the right balance of probiotics in our gut flora means that we are stronger against diseases and we are getting the right nourishment.

In order for probiotics to thrive and do its job, it needs prebiotics. Prebiotics are mostly fibre that human beings cannot digest, and they serve as the probiotics’ food. (3)

Because the gut flora is heavily reliant on our diets, it’s important that we feed the right kind of bacteria in our digestive systems. High-sugar and high-fat diets tend to be more beneficial to the “bad” bacteria, causing them to tip over the balance of the gut flora and overgrow. This can lead to obesity, higher risk of stroke and heart attack, and even cancer. (4)

Studies have shown that depression and other mental health issues may be connected to the proliferation of bad bacteria in the gut. In a study published in Trends In Neurosciences in 2016 (5), the idea of psychobiotics is expanded to include prebiotics, as opposed to just probiotics, as responsible for positively manipulating moods and alleviating depression, easing stress-related impact and managing insomnia.

More importantly, a study conducted at the National Yang-Ming University in Taiwan has identified a particular psychobiotic strain that has demonstrated an increase in the production of dopamine and serotonin levels. Psychobiotic PS128 is found to bridge the communication in our gut-axis better, allowing us to cope with stress by triggering a higher production of dopamine and serotonin, also known as the “happy” hormones. (6)

Psychobiotics aid in controlling the hormones in our brains that deal directly with moods and mental health. It helps in concentration and memory retention, as well as in promoting sleep and proper rest.

Synbiotics can be easily found in many food sources, though our fast-paced modern lifestyle sometimes does not account for the right amount in favour of quick, easily accessible but inevitably less nutritious food. Fulfil the right ratio of synbiotics in your diet by taking supplements that focus on your body and lifestyle needs.

To improve digestion and boost overall health, ActivKids Synbiotics makes for the easiest-to-take synbiotic vitamins. These convenient vitamins come in yummy bear form with three flavours: vanilla, orange and strawberry. Each yummy bear is filled with important prebiotic and probiotic strains that help improve digestion and immunity.

For those looking for clinically proven synbiotics, Multibiotics Active and Multibiotics Mind provide synbiotics with the Psychobiotic PS128 that you need to perform tasks better and improve mental health tenacity. Multibiotics Active is also supported with added Metabolic biotic K21 which helps fight inflammation, daytime fatigue and fat accumulation. At the same time, Multibiotics Mind contains Phosphatidylserine which helps improve memory and boosts concentration.

Shop now for your synbiotic and other supplement needs at wellbeingsg.com.

Probiotics: What You Need To Know. (2019, August). Retrieved August 24, 2020, from https://www.nccih.nih.gov/health/probiotics-what-you-need-to-know
Gunnars, K. (2018, November 13). Probiotics 101: A Simple Beginner’s Guide. Retrieved August 24, 2020, from https://www.healthline.com/nutrition/probiotics-101
Lewis, S. (2017, June 03). Probiotics and Prebiotics: What’s the Difference? Retrieved August 24, 2020, from https://www.healthline.com/nutrition/probiotics-and-prebiotics
Park, S. H., Kangwan, N., Park, J. M., Kim, E. H., & Hahm, K. B. (2013). Non-microbial approach for Helicobacter pylori as faster track to prevent gastric cancer than simple eradication. World journal of gastroenterology, 19(47), 8986–8995. https://doi.org/10.3748/wjg.v19.i47.8986
Sarkar, A., Lehto, S. M., Harty, S., Dinan, T. G., Cryan, J. F., & Burnet, P. (2016). Psychobiotics and the Manipulation of Bacteria-Gut-Brain Signals. Trends in neurosciences, 39(11), 763–781. https://doi.org/10.1016/j.tins.2016.09.002
Liu, W. , Chuang, H. , Huang, Y. , Wu, C. , Chou, G. , Wang, S. , & Tsai, Y. (2015). Alteration of behavior and monoamine levels attributable to Lactobacillus plantarum PS128 in germ-free mice. Behavioural Brain Research, 298 . doi: 10.1016/j.bbr.2015.10.046

When you’re a 20-something with your whole life in front of you, it’s easy to feel invincible. Young adults tend to push themselves to the limit: working hard, playing harder, and for some, partying hardest. However, running your body too hard too quickly has a comeuppance. Pushing yourself to your limit can open up your body to diseases, later on, so even though you think you’re healthy now, it’s best to arm yourself with supplements as early as possible. Supplements carry a stigma that they are only for the sick, pregnant, or heavily exercising.

However, supplements are helpful even when you’re at the peak of your youth. Now more than ever, the world is understanding the importance of a robust immune system and a healthy lifestyle. Here are two particular supplements that can change the trajectory of how you take care of yourself.

As humans, we primarily get the energy we need from our food. But also as humans, we have learned to take enjoyment from eating, which means that overindulging has become a norm and obesity has become one of the leading causes of heart diseases. While we should be careful of what we eat, helping our stomach break down food can make a huge difference. Enzymes are responsible for cutting up food in our stomach so they can be absorbed in our bodies, and though naturally occurring, we also gain natural enzymes from both animal and plant-based food.

However, as we age, enzyme production in our bodies slows and the food that is not broken down properly becomes a cause for indigestion, bloating, and bowel irregularities. It also means that we are not getting the full nutrition from the food we eat, especially when cooking food lessens the enzymes we naturally get from them. By taking enzyme supplements, we help our stomachs deal with big meals and the occasional cheat-day junk food. Aside from that, studies have also shown that digestive enzymes help ease Irritable Bowel Syndrome, some cases of muscle soreness following exercise, and some symptoms of arthritis.

Not all enzyme formulas are equal though. While adverse effects of digestive enzymes are minimal even when you consume a lot of it, some may still trigger side effects such as diarrhea, vomiting, and allergies. Some enzyme formulas in the market also rely on animal-based supplements which are not advisable for vegans and those with dairy or gluten allergies. Thankfully, Enzymedica Digest can rigorously break down fat, protein, fiber, and carbohydrates as a vegan and kosher supplement, and it is dairy and gluten-free. With its patent Thera-blend technology, Enzymedica Digest also works for a wider range of audiences, regardless of the pH levels found in your digestive system. This means that the enzymes in Enzymedica Digest will not break down even if you have an acidic or basic digestive system, allowing it to work 6 times faster and 3 times more effective than other supplements.

Heart disease is the leading cause of death globally. The key to a healthy lifestyle is a healthy heart, which is why cardio exercises and heart-healthy foods like fish are recommended for anybody who is health-conscious. But fish and its piscine taste may not be for everybody, and unless you’re willing to consume a huge amount of it, the Omega-3 fatty acids are best supplemented by fish oil. Because our bodies can only produce a small amount of Omega-3 fatty acids, we look for it in the food we eat in order to regulate the inflammation of our blood vessels and reduce plaque in the heart. However, a lot of the nutrients that we are supposed to consume are lost in the cooking and digestion of our food. To make sure we get the right amount of Omega-3, fish oil has become a popular choice to supplement the essential fatty acids needed for a healthier lifestyle, not only for those with heart disease but also for active individuals who need to take care of their hearts.

Eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) in particular are important to help lower blood pressure and support circulation. But many fish oil supplements in the market today do not meet the required daily intake (RDI) of EPA in your diet. They also often come with a fishy and unpleasant aftertaste. Good thing that there are formulations now that lessen the fishy burps while supplying the right amount of EPA that you need. Wiley’s Finest Alaskan Fish Oil Peak EPA is specially formulated to reduce or eliminate fishy burps altogether. Made from a single species and responsibly caught Wild Alaskan Pollock, these soft gel capsules are tested and certified by NSF International, an independent body that regularly tests food, water, and consumer products for high standards. Each gel capsule also contains 750 mg of EPA to make sure that you get the full benefit of your EPA RDI. Of course regular exercise and eating right can help build your stamina and take care of your body better. Add to that two supplements and you can enjoy a better work-life balance, optimizing your energy for things that matter to you. Find them both at www.wellbeingsg.com.

Carbone S, Canada JM, Billingsley HE, Siddiqui MS, Elagizi A, Lavie CJ. Obesity paradox in cardiovascular disease: where do we stand?. Vasc Health Risk Manag. 2019;15:89-100. Retrieved June 16, 2020, https://doi.org/10.2147/VHRM.S168946
Mótyán, J. A., Tóth, F., & Tőzsér, J. (2013). Research applications of proteolytic enzymes in molecular biology. Biomolecules, 3(4), 923–942. Retrieved June 16, 2020, from https://doi.org/10.3390/biom3040923
Money ME, Walkowiak J, Virgilio C, at a Pilot study: a randomized, double-blind, placebo-controlled trial of pancrelipase for the treatment of postprandial irritable bowel syndrome-diarrhea. Frontline Gastroenterology 2011;2:48-56. Retrieved June 16, 2020, from https://fg.bmj.com/content/2/1/48.info
Vuppala KK, Majeed M, Kumar AS, Majeed S, Vaidyanathan P (2016) Multi-Enzyme Complex for the Management of Delayed Onset Muscle Soreness after Eccentric Exercise: A Randomized, Double-Blind, Placebo-Controlled Study. Sports Nutr Ther 1: 113. DOI: 10.4172/2473-6449.1000113. Retrieved June 16, 2020, from https://www.omicsonline.org/open-access/multienzyme-complex-for-the-management-of-delayed-onset-musclesoreness-after-eccentric-exercise-a-randomized-double-blind-placeboc-2473-6449-1000113.php?aid=81357
Ameye, L.G., Chee, W.S. Osteoarthritis and nutrition. From nutraceuticals to functional foods: a systematic review of the scientific evidence. Arthritis Res Ther 8, R127 (2006). Retrieved June 17, 2020, from https://doi.org/10.1186/ar2016
Edakkanambeth varayil J, Bauer BA, Hurt RT. Over-the-counter enzyme supplements: what a clinician needs to know. Mayo Clin Proc. 2014;89(9):1307-12. Retrieved June 17, 2020, from https://arthritis-research.biomedcentral.com/articles/10.1186/ar2016
Cardiovascular Diseases. Retrieved June 17, 2020, from https://www.who.int/health-topics/cardiovascular-diseases/#tab=tab_1
Omega-3 Fatty Acids Fact Sheet For Consumers. Retrieved June 17, 2020, from https://ods.od.nih.gov/factsheets/Omega3FattyAcids-Consumer/
Culloch, M., M.S., R.D. 12 Benefits of Docosahexaenoic Acid (DHA). Published September 23, 2018. Healthline.com. Retrieved June 17, 2020, from, https://www.healthline.com/nutrition/dha-benefits#section9

The time has once again come for “New Year, New Me”!

As we tackle the new year ahead and return to work and school, it’s important to keep our health and mental wellness in check in the midst of our hectic schedules. At the same time, indulging in our new year celebrations during this time of the year can also give rise to gut troubles such as indigestion, bloating, and other digestive problems. Now is the perfect time to take a step back and assess the state of your gut and mental health, and to renew it if necessary.

Why Is Physical Wellness So Important?

Achieving physical wellness is one of the most important things you can achieve for your overall health. With physical wellness, you are able to do more things that you enjoy, which ultimately allows you to have a better quality of life. That being said, your gut flora, and consequently gut health, is the cornerstone of your physical wellness and overall health. It helps your body in the following ways:

• Digest the food you eat,
• Absorb the nutrients,
• Utilise these nutrients to maintain and power your body!

Having good gut health also maintains a strong immune system, which is vital in maintaining good overall health. A good immune system prevents a variety of problems, such as inflammation, chronic diseases, and chronic fatigue. Without a strong immune system, people consequently encounter symptoms including dizziness, brain fog, constipation, and gassiness, to name a few. If you’re currently noticing signs of poor gut health and are looking to improve it, it is vital to take action to renew your gut health. One way you can do this is to incorporate certain health supplements into your lifestyle!

For instance, our Multibiotics Active PS128 & K21 improves gut flora, immune system development, and bolsters our mental wellbeing and mobility. Taking Multibiotics Active will also relieve stress and anxiety, and improve your overall sleep quality.

Alternatively, consider opting for Enzymedica Digest to reduce your digestive discomfort and maximise your nutrition. The digestive supplement contains an optimal balance of enzymes which aids in complete digestion and ultimately helps you achieve a healthy and active gut. The enzymes in Digest function throughout the entire digestive system thanks to Thera-blendTM, enhancing your health benefits through a single supplement.

How About Mental Wellness?

Good mental health is essential to leading a happy life – it affects how you are able to function psychologically, emotionally and socially on a daily basis.

The benefits of having good mental health are plenty. It includes being able to deal with life’s challenges, maintaining physical health, having the ability to sustain fulfilling interpersonal connections, being effective at work, and reaching your full potential. This is especially important for growing children and teens, where good mental health will provide them with the resilience and ability to cope with life’s obstacles, which is a vital skill to be brought into adulthood. Increase and regulate your levels of dopamine and serotonin in your brain with ActivHealth’s Multibiotics Mind PS128. By lessening depression-like behaviors and reducing overall stress and anxiety, you can look forward to having a happier overall disposition in your daily life. On top of that, these multibiotics also alleviates irritable bowel syndrome (IBS) which also aids in maintaining a healthy gut.

The Bottom Line

Gut health and mental wellbeing are highly important aspects that every individual should consider, especially now as we step into the new year. As both of these have a great impact on overall health, start taking steps today to boost your gut health and mental wellness today!

Want to learn more about your physical and mental health together with ActivHealth? Sign up for our monthly newsletter, where we share more tips to help you on your journey to become a healthier and happier you.

 

Sources:

• https://www.ncbi.nlm.nih.gov/books/NBK279364/
• https://www.frederickhealth.org/news/2021/july/10-signs-of-an-unhealthy-gut/
• https://toronto.cmha.ca/documents/benefits-of-good-mental-health/